[Data] GC-MS analysis by solvent extraction

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This article introduces a pretreatment method to enable the analysis of substances that are difficult to analyze using GC/MS. The pretreatment that converts difficult-to-analyze substances into analyzable substances is called "derivatization." Methods such as esterification, acylation, and silylation are used selectively according to the types and characteristics of the difficult-to-analyze substances. GC/MS measurements were conducted on citric acid solutions and citric acid solutions after esterification. It was found that citric acid, being a carboxylic acid, could not be effectively detected without derivatization, but after esterification, trimethyl citrate was detected, confirming the presence of citric acid. By performing appropriate derivatization, more accurate analysis becomes possible.

This is an example of analyzing impurities confirmed from a solvent when high-purity products are stored in inappropriate environments using liquid injection GC-MS. Ethanol, stored in a light-protective reagent bottle in a cool, dark place, was transferred to a used plastic wash bottle and left at room temperature for about a month. As a result, impurities such as triethyl borate and alkylbenzenes were detected. Additionally, acetone, stored in a light-protective reagent bottle in a cool, dark place, was transferred to a transparent glass bottle without light protection and left at room temperature for about a month, resulting in the detection of diacetone alcohol as an impurity. For more details, please refer to the related products and catalog below.