Under various experimental conditions, the net membrane permeability of drugs and toxins can be measured.
The liquid inside each cell was completely mixed by the rotation of the stirrer. The thickness of the stagnant boundary layer formed on the membrane surface has been clarified under various stirring conditions, allowing for the determination of the net membrane permeation rate. The stirring drive device is a magnetic stirrer capable of continuous operation for long periods, which can simultaneously operate three sets of PERMCELL and can vary the stirring rotation speed over a wide range (approximately 500 rpm to 2000 rpm) depending on the type of membrane. There are two types of membrane mounting parts: one for flat membranes and one for spherical membranes, and in addition to the closed-type sample port stopper, a flow-type stopper is also available.
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basic information
■ In order to enable transmission experiments not only with flat membranes but also with spherical membranes, we have developed two types of cells for flat and spherical applications. These can be used for transmission experiments not only with synthetic membranes and skin but also with the skins of fruit trees and the cornea of the eyeball. ■ There are two sizes available (membrane area of approximately 5 cm² with a volume of 55 ml, and a membrane area of 0.6 cm² with a volume of 5 ml), allowing for selection based on the size of the membrane. ■ The temperatures on both the donor and receptor sides can be independently controlled via external jackets, enabling not only isothermal experiments but also a wide range of non-isothermal membrane transmission experiments using two circulating constant temperature baths. ■ The upper sample section of the cell can use both a closed stopper and a flow-type stopper depending on the purpose, allowing for flow-through (circulation type) transmission experiments when combined with an external pump. ■ The rotation speed of the magnetic stirrer can be freely controlled in the range of 500 rpm to 2000 rpm. The stirring condition within the cell is extremely good, and in most aqueous solution experiments, the influence of the stagnant boundary layer can be ignored, allowing for the direct measurement of the net membrane transmission rate.
Price information
Set price for large 3-stage flat membrane (KH-55PS)
Delivery Time
※It takes about one month if it comes with a stirrer.
Applications/Examples of results
It is used in experiments on membrane permeability for synthetic films, skin, cornea of the eyeball, and the skin of fruit juices.
Company information
In 1907, a glass processing business was established as a sole proprietorship in the Kita Ward of Osaka City, and in 1957, it was reorganized into a corporation in line with the development of the business, becoming what is now Fuji Rika Kogyo Co., Ltd. Our main operations include the production of glass products and the sale of scientific instrument manufacturer products. For over 100 years, we have steadily progressed alongside scientific glass and scientific instruments.
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