Quantitative Evaluation of Probe-Type Raman Indomethacin α/γ Mixed Polymorphic System
The heterogeneity of the sample governs the model design.
In this study, we conducted a quantitative evaluation of the indomethacin α/γ mixed system using probe-type Raman spectroscopy and examined the impact of model design on quantitative accuracy. In mixed polymorphic systems, the heterogeneity of samples due to differences in crystal morphology and dispersion state is unavoidable, and local measurements may reflect this influence in the quantitative results. Therefore, we constructed multiple models with different step widths and compared their behaviors in the evaluation of mixing ratios. The results suggest that quantitative accuracy strongly depends on model design tailored to the desired precision and concentration range, rather than the performance of the equipment itself.
- Company:テックアナリシス
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