Synthesize E-type alkenes with high efficiency!
This technology is a method for synthesizing E-alkenes in high yield through the selective reduction of alkynes. In conventional methods, the synthesis of E-alkenes from alkynes had low yield and selectivity, making it difficult to synthesize efficiently. This technology has achieved high-efficiency synthesis of E-alkenes by developing a novel aluminum-based complex. It is a versatile and low-cost synthesis method that does not require hazardous reagents or gases, nor expensive transition metals. Features of the technology: - High yield and high selectivity for synthesizing E-alkenes from internal and terminal alkynes. - Diverse alkene derivatives can be developed starting from the synthesized substituted alkenes. - No need for safety-considerate equipment or buildings; reactions can be conducted using conventional facilities.
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basic information
(Technical Content) New Hydroalumination Reaction Using Novel Aluminum Reagents ■ Using complexes of fluoride salts and di-substituted hydride aluminum ■ Synthesis of substituted alkenes - For internal alkynes, E-alkenes are produced with high yield, confirming high E-selectivity. - For terminal alkynes, a different stereoselectivity is observed compared to conventional methods. The bromination of the Al intermediate occurs with stereoselective Br addition. (Application Examples) ■ Versatile Alkene Synthesis Platform - Starting from substituted alkenes (intermediate A) synthesized by this method, it is possible to expand into multiple transformation reactions according to application. *For more details, please download the PDF or feel free to contact us.*
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Applications/Examples of results
(Fields where utilization is expected) It can be widely used in the development/manufacturing of compounds in pharmaceutical companies, various materials manufacturers, and contract synthesis manufacturers. - Raw materials and intermediates for pharmaceuticals - Raw material monomers for polymers, functional low molecular weight materials - Chemical synthesis intermediate raw materials
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Since our establishment, we have been supporting the commercialization of various companies. We have extensive experience and achievements in commercializing technologies developed at universities and launching new businesses utilizing subsidies. We will introduce researchers and technology seeds suitable for your company's product/technology development/research. Please feel free to contact us.
