The heterogeneity of the sample governs the model design.
In this study, we conducted a quantitative evaluation of the indomethacin α/γ mixed system using probe-type Raman spectroscopy and examined the impact of model design on quantitative accuracy. In mixed polymorphic systems, the heterogeneity of samples due to differences in crystal morphology and dispersion state is unavoidable, and local measurements may reflect this influence in the quantitative results. Therefore, we constructed multiple models with different step widths and compared their behaviors in the evaluation of mixing ratios. The results suggest that quantitative accuracy strongly depends on model design tailored to the desired precision and concentration range, rather than the performance of the equipment itself.
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Probe-type Raman spectrometer
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Applications/Examples of results
Content uniformity, crystallization polymorphism, quantification
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Company information
Our company supports the establishment of measurement methods, analytical techniques, and testing methods (analytical methods) using Raman spectroscopy, centered on vibrational spectroscopy, which can be utilized from research and development fields such as the evaluation of the physical properties of pharmaceutical raw materials and the dispersion state of solid dosage form particles to quality control fields such as acceptance testing. We provide support for the construction of analytical conditions, testing method settings, and validations. Please feel free to contact us if you have any requests.
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