Tohoku Univ. Technology ：Supercritical & Subcritical Fluid System：T22-178

High-Productivity, High-Quality Manufacturing for Pharmaceutical and Food Ingredients

The inventors have developed a unique subcritical solvent separation method using three green solvents—CO₂, ethanol, and water—to enable safe, eco-friendly production of pharmaceutical and food ingredients. Conventional supercritical and subcritical processes often face slurry freezing and clogging due to adiabatic expansion, reducing productivity and increasing maintenance time and cost. The proposed system prevents these issues by creating a controlled pressure difference between gas and liquid phases in the separation column, enabling a safer and more efficient extraction and manufacturing process. ◎High productivity enabled by continuous separation and collection ◎Handles slurry without clogging, reducing pretreatment time 　　　　　　 　　and preventing degradation of target compounds ◎No harmful organic solvents, ensuring safer and cleaner operations

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