Tohoku Univ. Technology:Skin microcirculation system: T11-045_T25-009

Non-invasive, minimally painful, and capable of continuous measurements equivalent to blood sampling.

■Introduction of Tohoku University Technology (T11-045) In order to grasp the state of health, biological components (blood sugar, lactic acid, etc.) are measured by blood sampling. However, since continuous measurement is difficult and invasive, the burden on the user is large. Therefore, the present invention provides a biological component measuring sensor which can measure biological components in real time for a long time and does not cause pain to the user. 　Specifically, a probe for measuring biological components has been developed which collects subcutaneous tissue fluid like dialysis by applying special processing to an ultra-fine needle inserted into the skin. A micro reflux needle with a channel covered with a perforated membrane on the surface of the metal needle is inserted and placed in the skin, and reflux fluid (physiological saline) is circulated through the channel. Since a substance in the skin tissue enters the reflux fluid through the hole in the channel due to concentration diffusion (osmotic pressure), the substance is flowed outside the body and the blood concentration is estimated from the concentration in the reflux fluid measured by a sensor installed outside the body. 　The present invention enables non-invasive, low-pain continuous measurement equivalent to blood sampling simply by attaching a micro-needle to the skin. *Please refer to the PDF file for related patent (T25-009).

others