The use of TOC in cleaning validation is gaining attention.
TOC is an effective tool for cleaning validation of pharmaceuticals, cosmetics, and medical devices. By using TOC for cleaning validation, it is possible to achieve quality improvement, risk reduction, and efficient operations. TOC is a simple analytical method that quickly detects low concentrations of organic compounds and can identify degradation products and contaminants that HPLC cannot detect. Compared to HPLC, which is a specific analytical method that detects only specific components, TOC, being a non-specific analytical method, can comprehensively confirm that excipients, degradation products, and cleaning agents are adequately cleaned. Furthermore, TOC simplifies method development and has less equipment downtime, leading to increased efficiency. By using TOC, not only can the cleaning process be evaluated quickly, but it also reduces workload, maintenance costs, and running costs compared to HPLC.
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basic information
The Sievers TOC analyzer accurately measures organic matter in samples without being affected by coexisting substances, thanks to its unique gas-permeable membrane conductivity measurement method. Sievers helps simplify method development and sample pretreatment. If the TOC concentration of a sample is unknown, the automatic reagent feature ensures complete oxidation of the organic matter. With Sievers' proven technological capabilities, excellent accuracy and recovery rates are guaranteed.
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Applications/Examples of results
Pharmaceutical cleaning validation Medical device cleaning validation Chemical cleaning evaluation Food and beverage cleaning evaluation
Company information
Since our establishment in 1967, we have been committed to the development and dissemination of water quality measuring instruments that anyone can use quickly, easily, and with high precision. In today's world, where effective utilization of the limited resource of water is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by leveraging our water quality measuring instruments, technology, and services. Additionally, we are dedicated to utilizing the latest technology and our years of expertise to deliver user-friendly and reliable water quality measuring instruments more affordably, quickly, and widely.
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