Tohoku University Technology: Compounds that suppress ferroptosis: T20-485
Vitamin K and its derivative
Ferroptosis is a form of regulated cell death associated with neurodegenerative diseases (e.g. Alzheimer's disease) and organ damage and is attracting attention as a therapeutic target. In this study, we found that vitamin K (especially the reduced form), a functional food ingredient, has a potent preventing effect on ferroptosis. Although a higher intake of vitamin K than those from the diet would be required to exert the anti-ferroptotic effect, vitamin K can be safely used even at high doses due to the no harmful effect reported. Thus, high-dose vitamin K supplementation is expected to be commercialized as a dietary supplement, functional food, and medicine.
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The revenue generated from technology transfer is reinvested into universities and researchers as new research funding, which is used to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will actively promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by concluding basic technology transfer agreements with the following universities (as of June 1, 2025): - Tohoku University - Hirosaki University - Iwate University - Akita University - Fukushima University - Yamagata University - Tohoku Gakuin University - Iwate Medical University - Fukushima Medical University - Aizu University - Miyagi University - Hokkaido University - Muroran Institute of Technology - Showa Medical University
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