Tohoku Univ. Technology : Novel Peptide Inhibitors for Alzheimer’s disease : T21-307
Notch‑Sparing Modulation of γ‑Secretase by Three‑Finger Toxins
Amyloid-β (Aβ) accumulation is a key driver of Alzheimer’s disease (AD). While γ-secretase inhibitors (GSIs) have long been pursued as therapeutics, safety issues have prevented their clinical adoption. Using AlphaFold2–based in-silico screening, the inventors discovered that Three-Finger Toxins (3FTXs)—disulfide-rich peptides from snake venom—potently block γ-secretase–mediated APP processing. Strong inhibitory activity was confirmed in both yeast-based assays and a β-galactosidase reporter system. Brain-targeted AAV vectors for 3FTX expression are currently under development, with evaluation in AD model mice planned. Acting at sites distinct from traditional GSIs, 3FTXs offer a novel and promising approach for AD prevention and treatment.
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The revenue generated from technology transfer is reinvested into universities and researchers as new research funding, which is used to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will actively promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by concluding basic technology transfer agreements with the following universities (as of June 1, 2025): - Tohoku University - Hirosaki University - Iwate University - Akita University - Fukushima University - Yamagata University - Tohoku Gakuin University - Iwate Medical University - Fukushima Medical University - Aizu University - Miyagi University - Hokkaido University - Muroran Institute of Technology - Showa Medical University
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