Case study of pharmaceutical analysis using forward scattering (transmission) Raman spectroscopy.
In the analysis of pharmaceutical tablets and capsules, it can be difficult to easily obtain information about the physical state and components of the active pharmaceutical ingredient inside the tablet or capsule due to interference from the tablet coating or capsule material. In this study, commercially available drugs with coatings and capsules filled with active pharmaceutical ingredients of different raw materials were used as model formulations. By employing forward scattering (transmission) Raman spectroscopy, we demonstrate that it is possible to reduce surface interference caused by the coating of the tablet or capsule and to analyze and evaluate the components.
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basic information
By connecting the forward scattering unit to the fiber connection port of the spectrometer, it became easy to measure Raman spectra, resulting in high versatility and the expectation of widespread adoption in the market. From the measurement results of tablets and capsules, it was revealed that using forward scattering can reduce the impact of film coating and provide more extensive information about the components. In the future, we would like to advance experiments and research towards new applications, such as applying it to content uniformity tests in formulation studies and evaluating the crystal forms of active ingredients in soft capsules.
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Applications/Examples of results
Analysis of active ingredients in coated tablets and capsule formulations.
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Company information
Our company supports the establishment of measurement methods, analytical techniques, and testing methods (analytical methods) using Raman spectroscopy, centered on vibrational spectroscopy, which can be utilized from research and development fields such as the evaluation of the physical properties of pharmaceutical raw materials and the dispersion state of solid dosage form particles to quality control fields such as acceptance testing. We provide support for the construction of analytical conditions, testing method settings, and validations. Please feel free to contact us if you have any requests.
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