PAT inline particle size, turbidity, and polymorphism monitoring device
BlazeMetrics Next-Generation PAT All-in-One Probe
The next generation all-in-one probe has been born. It accurately monitors the state of particles in reaction vessels and production lines with a single probe.
PAT Inline Particle Size, Turbidity, and Crystal Polymorphism Monitoring - Accurately grasp the state of particles with a single probe - Simultaneous measurement of particle size, turbidity, images, and Raman spectra - Particle size measurement unaffected by particle velocities up to 20 m/s - Installed on a single port, reducing installation/maintenance costs - Standard equipment in the USA, Europe, China, and India - Overseas, there is a tendency not to introduce new FRBM technology due to its outdated and inaccurate nature.
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basic information
- Blaze's patented single optical path technology allows multiple analytical techniques to utilize the same optical path simultaneously, enabling multiple measurements with a single probe. - The installation requires only one port, reducing setup time and maintenance while building a robust system. - With a single probe, the effects of baffle plate and heat sink from the probe can be minimized. - Integrating multiple measurement techniques enhances information. For example, explaining the particle size distribution (CLD) trend obtained from images with microscope images, correcting Raman intensity (Y-axis) using Blaze HDR turbidity to improve transition identification, and verifying the cleanliness of windows with microscope images. - With a single probe for multiple measurements, it is possible to measure small sample flow synthesis, etc. - By combining with microscope images, accurate information is obtained for determining material conditions, measurement zones, fouling (adhesion to inner walls, etc.), particle shapes, multiphase, polymorphism, etc. - Accurate information accelerates decision-making and shortens process development time. Understanding of the process improves more quickly, leading to a reduction in the number of experiments. - Total cost reduction: reduction in installation costs, operating costs, and maintenance costs.
Price information
The price varies depending on the contents of the options.
Delivery Time
Applications/Examples of results
Application Examples 1) Fine Particle Related - Optimization of reaction processes (Raman) - Examination of crystallization process conditions - Examination and management of formulation processes (granulation, milling) - Examination of API dissolution - Checking the mixing degree, segregation degree, and agglomeration degree of powders - Particle size management of slurries in battery manufacturing processes - Management of droplet size in emulsions 2) Coarse Particle Related - Monitoring of cells in bioreactors - Monitoring of clarity - Detection of foreign substances - Monitoring of protein aggregation
Detailed information
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According to FRBM's assumptions, let's stop process management. With Blazematrics, you can accurately grasp the state of particles. The FDA paper states that FRBM is inaccurate.
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You can choose from a variety of options to meet your needs.
Company information
Aivic Research was established with the aim of contributing to the improvement of healthcare by helping to enhance the accuracy of dissolution testing data through the provision of excellent dissolution testers and dissolution tester inspection services, as well as introducing the latest dissolution testing information utilizing various pipes from overseas to support the development of the pharmaceutical industry in Japan.
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