Tohoku Univ. Technology：Nucleic acid molecules that increase insulin-secreting beta cells：T14-170
New treatment concept for diabetes mellitus
It has been reported that reduction or deletion of Langerhans β cells (hereafter β cells) in pancreatic islet occurs not only in type 1 diabetes but also in type 2 diabetes. Therefore, regeneration or promotion of β cells has been proposed as a promising treatment for diabetes. Recently, it has been shown that the transplantation of bone marrow cells promotes the proliferation of β cells. However, the mechanism is not clear. The present invention relates to nucleic acid molecules that promote the proliferation of β cells. Said molecules increased insulin secretion and decreased blood glucose levels in animal model (right figure and related literature) in vivo. In combination with drug delivery systems, it is expected to establish a novel treatment for diabetes.
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The revenue generated from technology transfer is reinvested into universities and researchers as new research funding, which is used to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will actively promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by concluding basic technology transfer agreements with the following universities (as of June 1, 2025): - Tohoku University - Hirosaki University - Iwate University - Akita University - Fukushima University - Yamagata University - Tohoku Gakuin University - Iwate Medical University - Fukushima Medical University - Aizu University - Miyagi University - Hokkaido University - Muroran Institute of Technology - Showa Medical University
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