A case of poisoning that occurred during the process of washing crystals in a centrifuge using acetonitrile.
After transferring the crystals generated in the reaction vessel to a centrifuge and filtering them, we washed them with acetonitrile. However, due to insufficient washing, we switched to a kneading wash method that involved inserting hands into the centrifuge. We removed the duct of the local exhaust system of the centrifuge, which was obstructing the work, and while performing the task, we inhaled acetonitrile vapors, leading to exposure. The next day, four workers engaged in the kneading wash of the crystals reported feeling weak and went to the hospital for examination, where they were diagnosed with acetonitrile poisoning. [Suggestions] - Workers should wear personal PID monitors while working. - This will allow for monitoring exposure conditions and assist in the risk assessment of chemicals. *For more details, please refer to the PDF document or feel free to contact us.*
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【Case Overview】 ■Location of Occurrence ・Washing crystals using a centrifuge in the pharmaceutical manufacturing process ■Countermeasures ・When handling hazardous substances, confirm the dangers and hazards listed in the MSDS, equip necessary protective gear, and ensure its thorough use. *For more details, please refer to the PDF document or feel free to contact us.
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For more details, please refer to the PDF document or feel free to contact us.
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Riken Keiki Co., Ltd. was established as a company within the "Riken Foundation" conglomerate and has since focused on the scientific and technological advancements of the Riken Institute. As a specialized manufacturer of industrial gas detection and alarm equipment, we have worked to ensure industrial disaster prevention safety by preventing explosions caused by flammable gases and monitoring harmful gases in the workplace. Moving forward, we aim for zero loss of precious human lives and valuable assets, further strengthening our technological development capabilities. We will supply high-quality industrial gas detection and alarm equipment, as well as various excellent gas sensors, to countries around the world, contributing to the assurance of industrial disaster prevention safety.
