GeneDesign List of Products and Services

At Ajinomoto Bio-Pharma Services and Gene Design, we conduct a wide range of activities at our contract manufacturing facility specializing in nucleic acid pharmaceuticals, including GMP-compliant active pharmaceutical ingredient manufacturing, quality evaluation, and long-term stability testing. We offer flexible support from the development of manufacturing methods for non-clinical trials to small-scale trial production and manufacturing for clinical trials. Additionally, we have an isolator-integrated freeze-drying system that allows for the production of aseptic pharmaceuticals in small batches, which is ideal for cases where you want to keep clinical trial drug production on a small scale. 【Features】 ■ Flexible production of development items ■ Capable of supporting manufacturing method development and small-scale trial production ■ Supply of aseptic formulations ■ Complexation technology *For more details, please refer to the external link page or feel free to contact us.

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We offer double-stranded RNA "miRNA mimic" with chemical modifications on the passenger strand and double-stranded RNA "S-TuD" primarily composed of 2’-O-Methyl RNA. The "miRNA mimic" allows you to observe the activity of the mature miRNA itself by inactivating the passenger strand. The "S-TuD" specifically binds to the Micro RNA Binding Site (MBS) of the RISC complexed mature miRNA, powerfully inhibiting miRNA activity even at low concentrations. 【Features】 ■ miRNA mimic - Double-stranded RNA with chemical modifications on the passenger strand - Enables observation of the activity of the mature miRNA itself - Product developed based on results obtained from collaborative research ■ S-TuD - Double-stranded RNA primarily composed of 2’-O-Methyl RNA - Powerfully inhibits miRNA activity even at low concentrations - Negative control sequences are also available *For more details, please refer to the external link page or feel free to contact us.

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We provide various types of siRNA synthesis tailored to customer needs, delivered with high quality under thorough manufacturing management, including measures against RNase. 【Features】 ■ Delivered pre-annealed ■ Capable of synthesizing in vivo experimental grade ■ Special synthesis can accommodate insertions of LNA or UNA, as well as modifications such as 2’-O-Me and 2’-F Delivered in a double-stranded state, making it immediately usable for experiments. *For more details, please refer to the external link page or feel free to contact us.

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Ajinomoto Bio-Pharma Services and GeneDesign have extensive experience and a proven track record in LNA oligonucleotide synthesis and oligonucleotide synthesis that includes BNA. "LNA" is a type of synthetic nucleic acid known for its stability and specificity to complementary strands, while "BNA" is a general term for synthetic nucleic acids that are known to have high stability and increased specificity to complementary strands. Our company is capable of various modifications, including phosphorothioate modification and terminal modifications, in addition to long-chain DNA-LNA chimeric oligos and DNA-BNA chimeric oligos. 【Features】 ■ LNA Synthesis - Supplied by our company for research and development purposes - Supports terminal modifications, large-scale synthesis, and shipping for in vivo experimental grades ■ BNA Synthesis - Established technology for synthesizing and purifying oligonucleotides with various combinations - Provides LNA, BNA-NC (N-Me), and BNA-NC (N-H) *For more details, please refer to the external link page or feel free to contact us.

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At Ajinomoto Bio-Pharma Services Gene Design, we provide various types of custom RNA oligos tailored to our customers' needs, under our unique management system, ensuring high quality. We guarantee purity for up to 120 nucleotides and have a proven track record of synthesizing RNA up to 150 nucleotides in length. If you require longer chain lengths, please contact us. We offer a wide range of modifications, including 2'-F-RNA, 2'-OMe-RNA, LNA, and large-scale synthesis. 【Features】 ■ Synthesis scales (0.2μmol, 1μmol, mg guarantee) ■ Proven track record of synthesizing RNA up to 150 nucleotides ■ Purification grades (simple column purification, HPLC purification) ■ Special synthesis ■ Capable of synthesis at in vivo grade *For more details, please refer to the external link page or feel free to contact us.

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At Ajinomoto Bio-Pharma Services Gene Design, we provide high-quality oligonucleotide DNA that you can use with confidence, thanks to our consistent quality control from order to delivery. 【Synthesis Scale / Guaranteed Amount】 ■ 0.2 μmol scale synthesis ■ 1 μmol scale synthesis ■ mg, g, kg guarantee 【Quality Grade】 ■ Simple column purification ■ HPLC purification ■ in vivo ■ GMP 【Features】 ■ High-quality oligo DNA provided through technology cultivated over many years of experience ■ Abundant modification services (PS modification, 2'-OMe, 2'-MOE, LNA, etc.) ■ Many achievements in fluorescent modifications and functional compound modifications (PEG, peptides, etc.) *For more details, please refer to the external link page or feel free to contact us.

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At Ajinomoto Bio-Pharma Services Gene Design, we provide various nucleic acid drug seeds such as siRNA, aptamers, antisense, decoys, miRNA, and CpG-ODN, tailored to optimal specifications for cell assays, in vivo experiments, in vitro diagnostic pharmaceuticals, and clinical development investigational drugs compliant with GMP standards. We also offer fluorescent labeling such as Alexa modifications and detection probes like LNA oligos at reasonable prices to support your fundamental research. 【Features】 - Extensive experience with cross-linked nucleic acids such as LNA and BNA, various modifications including 2’-OMe RNA and 2’-F RNA, and peptide, PEG, and ligand terminal additions. - Process development and analytical method development with an eye toward scale-up. - Experience in examining and validating standard testing methods. - Conducting stability tests necessary for GLP studies and clinical development. For more details, please contact us or download the catalog.

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