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Medical hydrogel utilizing KGK's Makuringel technology!
Medical hydrogel with micro-adhesion that excels in repeated use and re-stickability. It has excellent shock absorption and conductivity, and is gentle on the skin.
Rapid Production of Cancer Stem Cells Driving Tumor Recurrence to Accelerate Cancer Research.
The average cancer recurrence rate is approximately 20%. For aggressive cancers, the recurrence rate within five years can be as high as 70%. Cancer stem cells, known for their resistance to radiation and drug therapies, are considered a key cause of recurrence. Recently, drug discovery research targeting cancer stem cells has attracted significant attention. However, the extremely low abundance of these cells within tumor tissues presents a major challenge for research. Several methods have been proposed to induce cancer stem cells from cancer cells. However, all require high culture costs and long induction times, making them impractical for clinical application. The present invention relates to a method of inducing cancer stem cells within 24 hours by culturing cancer cells on a double-network hydrogel (DN gel) without the use of drugs or genetic manipulation. Cancer stem cells induced by this method show increased expression of stem cell marker genes and exhibit tumor-forming ability even when injected in small numbers into mice. By enabling simple and rapid production of cancer stem cells, this method is expected to accelerate the development of cancer therapies. These therapies aim to achieve fundamental cures by preventing recurrence and metastasis.
A hydrogel composed of cellulose nanofibers derived from microorganisms, which is gentle on both humans and the environment.
It is a hydrogel composed solely of cellulose nanofibers, approximately 50nm in diameter, obtained through microbial fermentation, and water. It is produced using a method similar to that of nata de coco, which we consume. It has high water retention properties, with cellulose making up 1% of the hydrogel while retaining 99% water, allowing it to maintain moisture without drying out even when left at room temperature for extended periods. It is highly biocompatible and poses no harm when in contact with the human body. Additionally, it is an environmentally friendly material as it can be produced solely through fermentation without any chemical processing.
