Tohoku Univ. Technology：Improvement of Filamentous Fungi Using TAQing System：T22-154
Production of secondary metabolites derived from fungal dormancy genes
Many drugs have been developed from natural products produced by filamentous fungi. On the other hand, it has been reported that many biosynthetic genes of unexplored natural products that can be candidates for drugs are dormant on the genome of filamentous fungi. Using a large-scale genome rearrangement technology "TAQing system (A technique in which the restriction enzyme TAQI is introduced into a cell to simultaneously and multiply break DNA double strands, followed by recombination repair to produce a variety of genomic rearrangements)," the inventors generated a number of mutant strains of filamentous fungi in which dormant biosynthetic genes were activated, and succeeded in remarkably inducing the production of natural products not produced by wild strains. The development of a secondary metabolic activation method using the TAQing system has been investigated using the model filamentous fungus Aspergillus nidulans.
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The revenue generated from technology transfer is reinvested into universities and researchers as new research funding, which is used to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will actively promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by concluding basic technology transfer agreements with the following universities (as of June 1, 2025): - Tohoku University - Hirosaki University - Iwate University - Akita University - Fukushima University - Yamagata University - Tohoku Gakuin University - Iwate Medical University - Fukushima Medical University - Aizu University - Miyagi University - Hokkaido University - Muroran Institute of Technology - Showa Medical University
