Tohoku Univ. Technology：High-density culture of mutant filamentous fungi: T12-060
For mass fermentative production of useful substances!
Filamentous fungi have an advantage to produce a wide variety of useful substances in industry. However, it is well-known that hyphal aggregation during the liquid culture often prevents fungi to grow with high density, resulting in low productivity of useful substances. This invention discloses a mutant strain of a filamentous fungi, in which α-1,3-glucan synthase (AGS) gene is deficient, for high productivity of substances. The α-1,3-glucan in the cell wall in AGS deficient mutant (AGΔ) is significantly reduced. The AGΔ cells are dispersed well in a liquid medium and cultured with higher density compared with that of wild type. Such phenotype of AGΔ results in an increasing productivity of useful substances per unit.
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The revenue generated from technology transfer is reinvested into universities and researchers as new research funding, which is used to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will actively promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by concluding basic technology transfer agreements with the following universities (as of June 1, 2025): - Tohoku University - Hirosaki University - Iwate University - Akita University - Fukushima University - Yamagata University - Tohoku Gakuin University - Iwate Medical University - Fukushima Medical University - Aizu University - Miyagi University - Hokkaido University - Muroran Institute of Technology - Showa Medical University
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