バイオコム・システムズ List of Products and Services

"In vitro tests" are evaluations of the skin permeability of active ingredients in pharmaceuticals and cosmetics, as well as the release characteristics of topical preparations. These tests utilize animal skin (such as hairless mice and hairless rats), human skin (skin excised during cosmetic surgery abroad), cultured skin (three-dimensional cultured epidermis), and artificial membranes (such as Merck's Strat-M, a human skin substitute). The substances targeted include pharmaceuticals, quasi-drugs, cosmetics, and veterinary medicines. 【Equipment and Instruments】 ■ Vertical diffusion cells ■ Horizontal diffusion cells ■ High-performance liquid chromatography (HPLC) ■ Moisture evaporation measurement devices *For more details, please download the PDF or feel free to contact us.

• others

"SKIN-CAD" is a software for pharmacokinetic analysis of drugs in the skin and blood based on a transdermal absorption model. By inputting in vitro skin permeation data and known systemic pharmacokinetic parameters, it calculates the amount of transdermal absorption and the time course of blood concentration under clinical (in vivo) conditions. It can analyze the time course of blood concentration for systemic action drugs, the pharmacokinetics of local therapeutic drugs, and the skin permeation of active ingredients in cosmetics, depending on the purpose. 【Simulation Models】 ■ Skin permeation model (2-layer membrane or 1-layer membrane) ■ Drug dissolution matrix formulation/skin permeation model ■ Drug dispersion matrix formulation/skin permeation model ■ Formulation compartment/skin permeation model *For more details, please download the PDF or feel free to contact us.

• Other Software